Highlights include the unique ability of CR13626 to enter (and remain in) the brain, to selectively inhibit multiple tyrosine kinases (EGFR, VEGFR2, FYN and YES) that specifically fuel tumour growth, and to increase survival in a mouse model of glioblastoma
Monza (Italy), 18 September 2019
Rottapharm Biotech, an R&D company dedicated to innovative drug discovery and development, today announced that the key preclinical data of CR13626, its novel small molecule candidate for the treatment of glioblastoma, will be released at the 14th Meeting of the European Association of Neuro-Oncology (EANO) in Lyon, France, September 19-22, 2019.
The presentation “CR13626, an oral tyrosine kinase inhibitor crossing the blood brain barrier, reduces tumour growth and prolongs survival in a mouse model of glioblastoma”, will take place on 20 September.
“Glioblastoma is the most malignant form of primary brain cancer, and treatment options are still far from being optimal. Tumour heterogeneity and the inability of molecules to reach and stay in the brain, are among the main causes of therapeutic failure” said Dr. Lucio Rovati, CEO and CSO of Rottapharm Biotech. “CR13626 emerged from our large research program on kinase inhibitors as a product with the right characteristics for targeting glioblastoma”.
Dr. Gianfranco Caselli, director of Pharmacology and Toxicology at Rottapharm Biotech added “CR13626 selectively blocks multiple kinases relevant to glioblastoma and crosses the blood-brain barrier without being a substrate of the efflux transporters that push drugs out of the brain, thus contributing to tumour resistance. The present findings prove our original hypothesis: the unique ability of CR13626 to work efficiently in the brain tumour and surrounding microenvironment translates into a marked inhibition of cancer growth and a significantly increased survival of mice orthotopically implanted with human glioblastoma cells”.
The abstract is published in the Journal Neuro-Oncology and available online at https://academic.oup.com/neuro-oncology.